This advance has facilitated the development of mechanism-based therapies for migraine. 4 Further progress in understanding the pathogenesis has been made with the identification of signaling molecules that are involved in the genesis of a migraine attack. 4 Nociceptive signals from the trigeminovascular system are relayed to areas in the brain that yield the perception of migraine pain. 3Īlthough the pathogenesis of migraine is incompletely understood, it is considered to involve the trigeminal nerve and its axonal projections to the intracranial vasculature (termed the trigeminovascular system). 3 Some persons report that the migraine is preceded by an aura, which is characterized by reversible focal neurologic symptoms, typically comprising visual or hemisensory disturbances.
3 Common accompanying symptoms are nausea, vomiting, photophobia, and phonophobia. 3 A diagnosis of migraine should be considered if a typical attack of head pain is unilateral, pulsating, and aggravated by physical activity. 3 Broad clinical features suggestive of migraine are recurrent headache attacks of moderate-to-severe pain intensity, with a duration of 4 to 72 hours. 2 The diagnosis is based on clinical criteria provided by the International Classification of Headache Disorders, 3rd edition (ICHD-3). 1 According to the Global Burden of Disease Study 2016, migraine is the second leading cause of disability and accounts for more disability than all other neurologic disorders combined. Migraine is a ubiquitous neurologic disorder that is estimated to affect approximately 1 billion people worldwide, predominantly females. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident.
The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making.
0 kommentar(er)
